Derek Lowe
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How well can AlphaFold technology predict how drugs will fit into protein binding sites? Not so well, honestly. . .
https://www.science.org/co...
04:14 PM - Sep 07, 2023
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Derek Lowe
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There are too many clinical trials being run - well, too many bad ones with sketchy data, anyway:
https://www.science.org/co...
11:26 AM - Aug 10, 2023
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Derek Lowe
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AI-assisted protein design is moving so quickly that the field is almost unrecognizable now compared to a couple of years ago:
https://www.science.org/co...
01:03 PM - Aug 07, 2023
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Derek Lowe
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Re: that last Spout. This is not something that the law or the FDA overlooked. The law on nutritional supplements is deliberately written to keep FDA oversight to a minimum, and the crap described is the result.
02:55 PM - Aug 02, 2023
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Derek Lowe
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In case you were wondering, some of the nutritional supplements you might be taking can be loaded up with all kinds of junk (and none of what’s on the label):
https://www.science.org/co...
02:53 PM - Aug 02, 2023
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Derek Lowe
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More on the room-temperature superconductor work. I'm up to "guardedly optimistic" at this point, but there's a lot to be done to make sure this is real.
https://www.science.org/co...
11:10 AM - Aug 01, 2023
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Derek Lowe
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The scientific world this weekend is focused on the ever-changing situation around reports of a room-temperature superconductor. Labs around the world racing to confirm. If true, it could change the course of human history. https://www.science.org/co...
06:06 PM - Jul 29, 2023
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Derek Lowe
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I’m quoted in this article, and I think it’s a sadly accurate summary of the Alzheimer’s therapy field right now.
https://www.thenation.com/...
09:22 AM - Jul 27, 2023
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Derek Lowe
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Does the latest Alzheimer’s treatment even work? Does it do more good than harm? We will find out after it gets approved: https://www.science.org/co...
04:28 PM - Jul 25, 2023
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Derek Lowe
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How much of a big drug company’s portfolio is discovered by their own scientists? A look at six recent years of FDA approvals:
https://www.science.org/co...
12:27 PM - Jul 24, 2023
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Derek Lowe
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Turns out that the coronavirus has another way to enter our cells (besides the now-famous ACE2 protein):
https://www.science.org/co...
11:51 AM - Jul 19, 2023
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Derek Lowe
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We’ve found exactly the way you don’t want to extend lifespan, and it might help to aim toward the ways that we do:

https://www.science.org/co...
01:42 PM - Jul 18, 2023
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Derek Lowe
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A way that tumor cells fight back against chemotherapy - and how some types of chemotherapy might actually be activating it:
https://www.science.org/co...
12:57 PM - Jul 17, 2023
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Derek Lowe
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A very high-stakes situation is playing out over whether s research team has discovered a whole new class of amazing superconductors - or if it’s all a mistake:
https://www.science.org/co...
02:52 PM - Jul 13, 2023
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Derek Lowe
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As someone who did years of research on metabolic drugs, I find the data from the newest GLP-1 drugs startling indeed:
https://www.science.org/co...
01:24 PM - Jul 11, 2023
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Derek Lowe
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Methamphetamine comes in two mirror image forms. One is of course a famous drug of abuse. What’s the other one do?

https://www.science.org/co...
02:43 PM - Jul 10, 2023
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Derek Lowe
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Could the unusual amino acid taurine be a powerful anti-aging compound? A new study makes an intriguing case:

https://www.science.org/co...
08:57 AM - Jul 07, 2023
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Derek Lowe
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We might have actually found out where the mysterious chiral “handedness” of life as we know it came from:
https://www.science.org/co...
04:56 PM - Jun 29, 2023
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Derek Lowe
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The FDA has been approving too many drugs on the basis of wishful thinking:
https://www.science.org/co...
04:35 PM - Jun 27, 2023
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Derek Lowe
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A new report of a new biopharma company that’s having trouble replicating the results that raised them > $300 million in funding. But the warning signs were there - and so often they’re the same ones:
https://www.science.org/co...
01:33 PM - Jun 26, 2023
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Derek Lowe
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If this works, it’ll be a “best of both worlds” vaccine technology:
https://www.science.org/co...
08:32 PM - Jun 20, 2023
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Derek Lowe
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A clinical trial showed a placebo-controlled benefit in “Long Covid” patients. But we’re not sure how - or not yet.
https://www.science.org/co...
04:50 PM - Jun 15, 2023
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Derek Lowe
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We have a Big Legal Situation coming up in the biopharma industry, as Merck sues to stop the Medicare pricing provisions of the Inflation Reduction Act. This cannot help but get messy:
https://www.science.org/co...
09:44 AM - Jun 14, 2023
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Derek Lowe
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Wholesale fakery of scientific papers: “paper mills” in China and other countries will generate completely bogus manuscripts for you and attach your name to them. And they’ll even work on bribing journal editors if you need that:

https://www.science.org/co...
10:02 AM - Jun 13, 2023
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Derek Lowe
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Will reducing Tau protein be a therapy for Alzheimer’s? We’ve never been sure, but we might be about to find out:
https://www.science.org/co...
03:51 PM - Jun 12, 2023
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Derek Lowe
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What AI and machine learning can’t do for us in chemistry and in biopharma - and why it falls short:
https://www.science.org/co...
02:34 PM - Jun 02, 2023
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Derek Lowe
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What does ketamine do for depression, and how does it do it? Puzzling new evidence:
https://www.science.org/co...
02:44 PM - May 31, 2023
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Derek Lowe
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Did a famous early synthesis of a chain-linked “catenane” compound actually work back in 1960, or was it wishful thinking.

Now we (and the 93-year-old author!) know:

https://www.science.org/co...
04:48 PM - May 30, 2023
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Derek Lowe
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How exactly did ibuprofen get so cheap? The (very) inside story:

https://www.science.org/co...
04:17 PM - May 22, 2023
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Derek Lowe
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Another type of brain cell thsn we realized seems to be involved in the effects of general anesthesia:
https://www.science.org/co...
02:08 PM - May 17, 2023
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