How well can AlphaFold technology predict how drugs will fit into protein binding sites? Not so well, honestly. . .
https://www.science.org/content/blog-post/docking-alphafold-structures-oops
https://www.science.org/content/blog-post/docking-alphafold-structures-oops
04:14 PM - Sep 07, 2023
There are too many clinical trials being run - well, too many bad ones with sketchy data, anyway:
https://www.science.org/content/blog-post/too-many-bad-clinical-trials
https://www.science.org/content/blog-post/too-many-bad-clinical-trials
11:26 AM - Aug 10, 2023
AI-assisted protein design is moving so quickly that the field is almost unrecognizable now compared to a couple of years ago:
https://www.science.org/content/blog-post/protein-design-ai-way
https://www.science.org/content/blog-post/protein-design-ai-way
01:03 PM - Aug 07, 2023
Re: that last Spout. This is not something that the law or the FDA overlooked. The law on nutritional supplements is deliberately written to keep FDA oversight to a minimum, and the crap described is the result.
02:55 PM - Aug 02, 2023
In case you were wondering, some of the nutritional supplements you might be taking can be loaded up with all kinds of junk (and none of what’s on the label):
https://www.science.org/content/blog-post/what-s-those-supplements-again
https://www.science.org/content/blog-post/what-s-those-supplements-again
02:53 PM - Aug 02, 2023
More on the room-temperature superconductor work. I'm up to "guardedly optimistic" at this point, but there's a lot to be done to make sure this is real.
https://www.science.org/content/blog-post/room-temperature-superconductor-new-developments
https://www.science.org/content/blog-post/room-temperature-superconductor-new-developments
11:10 AM - Aug 01, 2023
The scientific world this weekend is focused on the ever-changing situation around reports of a room-temperature superconductor. Labs around the world racing to confirm. If true, it could change the course of human history. https://www.science.org/content/blog-post/breaking-superconductor-news
06:06 PM - Jul 29, 2023
I’m quoted in this article, and I think it’s a sadly accurate summary of the Alzheimer’s therapy field right now.
https://www.thenation.com/article/society/alzheimers-drugs/
https://www.thenation.com/article/society/alzheimers-drugs/
09:22 AM - Jul 27, 2023
Does the latest Alzheimer’s treatment even work? Does it do more good than harm? We will find out after it gets approved: https://www.science.org/content/blog-post/lilly-s-alzheimer-s-data-donanemab
04:28 PM - Jul 25, 2023
How much of a big drug company’s portfolio is discovered by their own scientists? A look at six recent years of FDA approvals:
https://www.science.org/content/blog-post/drugs-2015-2021
https://www.science.org/content/blog-post/drugs-2015-2021
12:27 PM - Jul 24, 2023
Turns out that the coronavirus has another way to enter our cells (besides the now-famous ACE2 protein):
https://www.science.org/content/blog-post/another-coronavirus-entry-point
https://www.science.org/content/blog-post/another-coronavirus-entry-point
11:51 AM - Jul 19, 2023
We’ve found exactly the way you don’t want to extend lifespan, and it might help to aim toward the ways that we do:
https://www.science.org/content/blog-post/longer-life-cost
https://www.science.org/content/blog-post/longer-life-cost
01:42 PM - Jul 18, 2023
A way that tumor cells fight back against chemotherapy - and how some types of chemotherapy might actually be activating it:
https://www.science.org/content/blog-post/one-way-tumor-cells-fight-back
https://www.science.org/content/blog-post/one-way-tumor-cells-fight-back
12:57 PM - Jul 17, 2023
A very high-stakes situation is playing out over whether s research team has discovered a whole new class of amazing superconductors - or if it’s all a mistake:
https://www.science.org/content/blog-post/superconductor-chaos
https://www.science.org/content/blog-post/superconductor-chaos
02:52 PM - Jul 13, 2023
As someone who did years of research on metabolic drugs, I find the data from the newest GLP-1 drugs startling indeed:
https://www.science.org/content/blog-post/new-world-obesity-therapies
https://www.science.org/content/blog-post/new-world-obesity-therapies
01:24 PM - Jul 11, 2023
Methamphetamine comes in two mirror image forms. One is of course a famous drug of abuse. What’s the other one do?
https://www.science.org/content/blog-post/other-methamphetamine
https://www.science.org/content/blog-post/other-methamphetamine
02:43 PM - Jul 10, 2023
Could the unusual amino acid taurine be a powerful anti-aging compound? A new study makes an intriguing case:
https://www.science.org/content/blog-post/taurine
https://www.science.org/content/blog-post/taurine
08:57 AM - Jul 07, 2023
We might have actually found out where the mysterious chiral “handedness” of life as we know it came from:
https://www.science.org/content/blog-post/origin-chiral-biomolecules
https://www.science.org/content/blog-post/origin-chiral-biomolecules
04:56 PM - Jun 29, 2023
The FDA has been approving too many drugs on the basis of wishful thinking:
https://www.science.org/content/blog-post/hope-sale-get-your-hope-now
https://www.science.org/content/blog-post/hope-sale-get-your-hope-now
04:35 PM - Jun 27, 2023
A new report of a new biopharma company that’s having trouble replicating the results that raised them > $300 million in funding. But the warning signs were there - and so often they’re the same ones:
https://www.science.org/content/blog-post/always-same-warning-signs
https://www.science.org/content/blog-post/always-same-warning-signs
01:33 PM - Jun 26, 2023
If this works, it’ll be a “best of both worlds” vaccine technology:
https://www.science.org/content/blog-post/towards-improved-vaccine-technology
https://www.science.org/content/blog-post/towards-improved-vaccine-technology
08:32 PM - Jun 20, 2023
A clinical trial showed a placebo-controlled benefit in “Long Covid” patients. But we’re not sure how - or not yet.
https://www.science.org/content/blog-post/long-covid-shows-card
https://www.science.org/content/blog-post/long-covid-shows-card
04:50 PM - Jun 15, 2023
We have a Big Legal Situation coming up in the biopharma industry, as Merck sues to stop the Medicare pricing provisions of the Inflation Reduction Act. This cannot help but get messy:
https://www.science.org/content/blog-post/drug-pricing-restrictions-oh-joy
https://www.science.org/content/blog-post/drug-pricing-restrictions-oh-joy
09:44 AM - Jun 14, 2023
Wholesale fakery of scientific papers: “paper mills” in China and other countries will generate completely bogus manuscripts for you and attach your name to them. And they’ll even work on bribing journal editors if you need that:
https://www.science.org/content/blog-post/fakin-it-modern-way
https://www.science.org/content/blog-post/fakin-it-modern-way
10:02 AM - Jun 13, 2023
Will reducing Tau protein be a therapy for Alzheimer’s? We’ve never been sure, but we might be about to find out:
https://www.science.org/content/blog-post/reduction-tau
https://www.science.org/content/blog-post/reduction-tau
03:51 PM - Jun 12, 2023
What AI and machine learning can’t do for us in chemistry and in biopharma - and why it falls short:
https://www.science.org/content/blog-post/give-me-those-hard-hard-numbers
https://www.science.org/content/blog-post/give-me-those-hard-hard-numbers
02:34 PM - Jun 02, 2023
What does ketamine do for depression, and how does it do it? Puzzling new evidence:
https://www.science.org/content/blog-post/what-exactly-does-ketamine-do-depression
https://www.science.org/content/blog-post/what-exactly-does-ketamine-do-depression
02:44 PM - May 31, 2023
Did a famous early synthesis of a chain-linked “catenane” compound actually work back in 1960, or was it wishful thinking.
Now we (and the 93-year-old author!) know:
https://www.science.org/content/blog-post/did-compound-ever-exist
Now we (and the 93-year-old author!) know:
https://www.science.org/content/blog-post/did-compound-ever-exist
04:48 PM - May 30, 2023
How exactly did ibuprofen get so cheap? The (very) inside story:
https://www.science.org/content/blog-post/ibuprofen-revolution
https://www.science.org/content/blog-post/ibuprofen-revolution
04:17 PM - May 22, 2023
Another type of brain cell thsn we realized seems to be involved in the effects of general anesthesia:
https://www.science.org/content/blog-post/knocked-out-microglia
https://www.science.org/content/blog-post/knocked-out-microglia
02:08 PM - May 17, 2023