Aviral Vatsa

Aviral Vatsa

@Docvatsa

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43 Spouts 348 Followers 6 Following

GP NHS Scotland, Scientist. Evidence based medicine. COVID. LongCovid. Sports Medicine

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@Docvatsa

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Thread.
1. Some of the ways how SARS Cov2 is affecting us as Long COVID (LC):
- Immune dysregulation
- Auto immune disease
- micro clots
- viral debris
- persistence of SARS virus
- Viral reactivation- e.g. EBV, CMV
- end organ damage

It is one of the worst viruses to impact us. Stay safe

11:40 AM - Mar 25, 2023

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@Docvatsa

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'COVID emergency is over ' (not COVID), says WHO .

Do remember that it continues to debilitate us in many different ways, causing chronic illnesses.

Some will understand it now, some in a few years and a few perhaps never.

Meanwhile, SARS will continue its 'impact' ☹️

05:18 AM - May 19, 2023

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@Docvatsa

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The covid minimisers, anti-vaxxers, and policymakers have endangered our children's health for years to come. Simpler solutions today would have saved a lot of heartache down the line.

Long Covid risks in kids are worrisome.

https://www.jpeds.com/arti...

08:06 PM - May 14, 2023

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@Docvatsa

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An estimated 20% chance of an Omicron like new variant to spread. Of course not to panic about it, and surely not to ignore it either.

Living with the virus shud mean by taking apt precautions timely & scientifically.

https://edition.cnn.com/20...

Covid-19 experts say they warned White House about chance of an Omicron-level event within the next two years | CNN

In March, the White House reached out to about a dozen Covid-19 experts who are closely following the evolution of the coronavirus to ask a simple question: What did they think were the chances of the world seeing a highly mutated variant, akin to Omicron, within the next two years?

10:25 AM - May 06, 2023

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@Docvatsa

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It seems the emergency bit of COVID is 'over' as per WHO.

Can someone convey this to the virus too please, that it's time to stop killing people and stop making them sick for months/years? And also pls stop new variants. Thanks.

https://www.bbc.co.uk/news...

Covid global health emergency is over, WHO says - BBC News

Close to 20 million people are likely to have died during the last three years, says the WHO.

12:47 PM - May 05, 2023

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@Docvatsa

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Great News.
RSV vaccine has been approved.
RSV kills 6k- 10k over 65 annually.
94% effective in reducing serious illness & 82.6% in reducing symptomatic infection in 60+ .
It has been a long wait for this one.

https://interestingenginee...

FDA approves world’s first ‘respiratory syncytial virus’ vaccine

According to the vaccine phase III clinical-trial data, its efficacy in reducing symptomatic infection in adults aged 60 and older is 82.6 percent.

05:20 AM - May 04, 2023

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@Docvatsa

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1 in 10 have post COVID symptoms. - WHO

Re-infections ? Herd immunity? 😡

09:27 AM - Apr 27, 2023

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thread

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A significant development to decipher specific markers for severe disease in children, after SARS CoV 2 infection.
Hopefully a diagnostic test will solve this soon.

https://www.technologynetw...

Biomarker Patterns Unique to MIS-C Identified | Technology Networks

Using powerful sequencing technology, researchers have identified specific biomarker patterns in the blood that are unique to severe COVID-19 infection, as well as others unique to Multisystem Inflammatory Syndrome in Children.

09:17 AM - Apr 27, 2023

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@Docvatsa

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Some day we all shall realise the real importance of masking up, hopefully. I mean the policy makers will pay heed to science.

https://www.news-medical.n...

Infectious particles of the SARS-CoV-2 virus isolated from hospital air

Quebec scientists have succeeded in isolating infectious particles of the SARS-CoV-2 virus from air samples collected from hospital rooms of COVID-19 patients and kept frozen for more than a year, a new study shows.

12:14 AM - Apr 21, 2023

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Risk of new cases of diabetes is higher in people who had SARS Cov2 than who did not.
Younger males, severe disease were worse off.
Clearly COVID is adding to our health care burden both at individual and population level.

https://jamanetwork.com/jo...

11:26 PM - Apr 18, 2023

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@Docvatsa

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Proper mechanical ventilation in schools can do wonders in controlling COVID infection in kids. More evidence screams for ventillation as a key strategy against covid spread.

https://www.reuters.com/wo...

Italian study shows ventilation can cut school COVID cases by 82% | Reuters

An Italian study published on Tuesday suggests that efficient ventilation systems can reduce the transmission of COVID-19 in schools by more than 80%.

03:17 AM - Apr 17, 2023

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@Docvatsa

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Do you hit your head on a concrete wall every three months, hoping that if you survive you will have a stronger skull? If not, why let into your system a virus, which significantly worsens your risks for stroke, heart attacks, severe breathlessness among many others?

02:04 AM - Apr 13, 2023

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@Docvatsa

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Vaccination induced Immunity rapidly acts from day 1 after a breakthrough infection & peaks by day 5. This likely prevents the severe disease.
Spike-specific CD8+ activation correlates with the viral clearance

https://www.cell.com/immun...

SARS-CoV-2 breakthrough infection induces rapid memory and de novo T cell responses: Immunity

Our understanding of T cell responses to SARS-CoV-2 vaccination and breakthrough infection has lagged behind B cells and antibodies. Here, Koutsakos et al. utilize longitudinal sampling to demonstrate a rapid activation of SARS-CoV-2-specific CD4+ and CD8+ T cells during breakthrough ..

05:30 PM - Apr 11, 2023

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@Docvatsa

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A welcome step for science to move forward, hopefully, at a faster speed than the virus. The anti vaxxers too can find new hypothetical targets. A win win situation :).

https://www.washingtonpost...

White House launches $5B program to speed covid vaccine development - The Washington Post

‘Project Next Gen’ would succeed ‘Operation Warp Speed’ with a mission to develop next-generation vaccines and therapies.

06:27 PM - Apr 10, 2023

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A relatively new study examined the association of COVID-19 with incident cardiovascular events in 17,871 UK Biobank cases between March 2020 and 2021.

A thread. 1/n

https://heart.bmj.com/cont...

Cardiovascular disease and mortality sequelae of COVID-19 in the UK Biobank | Heart

Objective To examine association of COVID-19 with incident cardiovascular events in 17 871 UK Biobank cases between March 2020 and 2021. Methods COVID-19 cases were defined using health record linkage. Each case was propensity score-matched to two uninfected controls on age, sex, deprivation, body ..

12:19 PM - Apr 10, 2023

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@Docvatsa

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If you are worried about dementia, there is an intervention that can substantially delay the risks.
Exercise. Just that.

A study highlights the delay in dementia by over 9 years, studied over 44 years in 1462 women aged 38 to 60.
Get up n move (if u can)

https://n.neurology.org/co...

Midlife cardiovascular fitness and dementia | Neurology

Objective To investigate whether greater cardiovascular fitness in midlife is associated with decreased dementia risk in women followed up for 44 years. Methods A population-based sample of 1,462 women 38 to 60 years of age was examined in 1968. Of these, a systematic subsample comprising 191 women..

01:37 AM - Apr 10, 2023

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@Docvatsa

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Altered taste, smell, brain fog improved in 12% while late onset cough and hearing issues started in 12% of the cohort.

This Scotland wide longer term study shows hope for some and concerns for other symptoms in the longer term

https://www.researchsquare...

10:15 PM - Apr 09, 2023

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@Docvatsa

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Even if one had asymptomatic SARS Cov2 , there are risks of longer term effects. These risks are lower than after a symptomatic infection, but are not zero.
This virus has changed us forever (in case you had missed that observation).

https://www.ncbi.nlm.nih.g...

Long-Term Consequences of Asymptomatic SARS-CoV-2 Infection: A Systematic Review and Meta-Analysis - PMC

Little is known about the long-term consequences of asymptomatic infection caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We aimed to review the data available to explore the long-term consequences of asymptomatic SARS-CoV-2 infection ...

09:56 PM - Apr 09, 2023

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@Docvatsa

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Our eyes also hace ACE2 receptors. New variant XBB.1.16, spreads faster & sticks stronger to ACE2.
Anecdotally, kids with covid r getting sticky eyes more commonly.
Cases rising sharply in India. No mitigations. Fingers crossed.

https://tactnowinfo.substa...

Conjunctivitis/Pink Eye Like Symptoms May Be the XBB.1.16 Variant. COVID can Pass to a Baby, Causing Brain Damage and Death in Some Pregnant Women.

XBB.1.16 has jumped to 11% prevalence in NJ

03:14 PM - Apr 09, 2023

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Pre-print.
COVID impact in pregnancy (neglected topic).

Various strains have varying negative impacts on both mother & foetus/infant.
Delta was perhaps the worst.

Please continue precautions, vaccinations & genomic sequencing.

https://www.medrxiv.org/co...

Risk of Adverse Maternal and Fetal Outcomes Associated with COVID-19 Variants of Concern: A Sequential Prospective Meta-Analysis | medRxiv

medRxiv - The Preprint Server for Health Sciences

02:52 PM - Apr 09, 2023

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Anti vaxxing propaganda starts from people running multi million dollar companies. Others just follow like sheep. Connect the dots.

Shutting eyes is the laziest thing one can do to evidence.

https://www.nature.com/art...

Dismantling the anti-vaxx industry | Nature Medicine

Investigations show that those spreading misinformation that undermines the rollout of vaccines against COVID-19 are well financed, determined and disciplined. To counter their activities, we need to understand them as an industry actively working to sow doubts about the deadliness of COVID-19, vacc..

09:05 PM - Apr 06, 2023

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You had COVID? There is a very high chance that you are carrying the spike protein in your head. Physically that is.
FYI only.

https://www.biorxiv.org/co...

SARS-CoV-2 Spike Protein Accumulation in the Skull-Meninges-Brain Axis: Potential Implications for Long-Term Neurological Complications in post-COVID-19 | bioRx..

bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution

01:42 PM - Apr 06, 2023

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If you missed it.

SARS-CoV-2 infection damages the CD8+ T cell response in unvaccinated (reduced immune response to spike proteins)
Vaccinations- robust response.
Unvaccinated? think again!

https://www.nih.gov/news-e...

SARS-CoV-2 infection weakens immune-cell response to vaccination | National Institutes of Health (NIH)

NIH-funded study suggests need to boost CD8+ T cell response after infection.

07:02 PM - Apr 05, 2023

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'The Covid' which was 'over' long ago has consumed 10,300 lives in 2022 vs 1400 in 2021 in Australia.😢

Why are they still testing, recording, spreading fear? Stop testing like the rest? 😡😡

https://www.1news.co.nz/20...

Covid skyrockets to third leading cause of death in Australia

It's raised a dire warning from experts who insist the pandemic is not over despite widespread messaging to the contrary.

06:47 PM - Apr 05, 2023

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Health authorities warn hikers of a virus spread by ticks causing 3 cases of encephalitis since 2019.👍

Psst!
SARS Cov2 cont to cause serious issues in millions. Just saying.

https://www.theguardian.co...

Hikers urged to check themselves for ticks after deadly virus found in UK | Health | The Guardian

Risk of tick-borne encephalitis virus is very low, but infection can be life threatening

06:30 PM - Apr 05, 2023

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OMG link between bivalent Covid vaccines and cardiovascular risks … studied … and NO link found.

Anti vaxxers, twist this, don’t open ur eyes to evidence & carry on endangering human lives by spreading wrong info.

https://www.nejm.org/doi/f...

06:14 PM - Apr 05, 2023

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Aviral Vatsa echoed

Elizabeth Murray

@DrElizabethMurray

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This is infuriating! We’ve been here, unless we buy a blue check, no one sees our tweets. Major academic centers allow disinformation spreaders to keep their appointments. Medical licensing agencies do almost nothing. Maybe take down the disinformation spreaders. https://www.statnews.com/2...

White House Covid adviser calls on docs to combat misinformation

The coordinator of the White House Covid response team called on doctors to take a leadership role in battling medical misinformation.

01:43 PM - Apr 03, 2023

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For the last three years all of us have been through a lot, and made it alive.
Many many still suffer from pain, reduced quality of life, worsened finances, further risks ...
Be mindful, be kind. Stay updated, stay protected.

06:59 AM - Apr 02, 2023

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While the researchers prepare better 4 future pandemics, govt policies continue to undermine mitigations, support, data collection for current pandemic.

Only if govts cud b more scientific!

https://www.theguardian.co...

UK develops genetic early warning system for future pandemics | Epidemics | The Guardian

Project aims to roll out cheap, easy-to-use technology across the globe to spot emergence of new health threats

06:51 AM - Apr 02, 2023

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Exercise is a very tricky modality in Long COVID. Rightly, NIH is being asked to reconsider the dangers involved in studying it in its trials in the current form.
Hopefully more nuanced and better targeted approach prevails.

https://www.nature.com/art...

Long COVID exercise trials proposed by NIH raise alarm

Advocates ask the US biomedical agency to rethink the design of its RECOVER initiative, citing possible harm and funding waste.

06:26 AM - Apr 02, 2023

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#SportsMedicine

Dear elite athletes, athletes and everyone :),

If there are two things you can do to keep good health and increase performance, please ensure great sleep and well-maintained oral health (often neglected)

It will work wonders.

https://pubmed.ncbi.nlm.ni... (pls

01:09 PM - Apr 01, 2023

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