Christopher Bouzy
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Twitter is the largest far-right platform on the planet.
04:09 AM - Jun 21, 2023
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Satoshi Akima
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thread 8 Threaded Spouts
Metformin monotherapy reminds me of AZT. On its own, the antiviral effect is minor but the magic only happened in antiretroviral therapy when they started to combine drugs with different mechanisms.
09:57 PM - Jun 10, 2023
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Satoshi Akima
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thread 8 Threaded Spouts
I'm old enough to recall the controversy around AZT in HIV and whether it did anything. There was much debate, but then a meta-analysis showed a small survival benefit. It was tiny, but it was still a triumph because it was the first time an antiretroviral had been proven to work
09:57 PM - Jun 10, 2023
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Satoshi Akima
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thread 8 Threaded Spouts
The COVID-OUT authors state: “The fluvoxamine group was closed on Jan 7, 2022, by the independent data and safety monitoring board.” It was not ethical to continue trialling a proven homeopathic drug dose. Whoops. https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(23)00299-2/fulltext
09:57 PM - Jun 10, 2023
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Satoshi Akima
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thread 8 Threaded Spouts
The Lancet study clearly states this: “For fluvoxamine, placebo-controlled trials showed no clinical effect with 50 mg twice daily (ACTIV-6) and clinical benefit with 100 mg twice daily (TOGETHER trial).” Meta-analyses agree with this.
09:55 PM - Jun 10, 2023
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Satoshi Akima
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thread 8 Threaded Spouts
By comparison to the homeopathic dose of Fluvoxamine, 1500 mg/day of Metformin is quite a decent dose of the drug and they uptitrate to this target dose much faster than is typical when treating diabetes with this drug.
09:54 PM - Jun 10, 2023
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Satoshi Akima
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thread 8 Threaded Spouts
The BMJ editorial also states, “Other arms of the trial looked at…fluvoxamine and found that [it did not decrease] the risk of long COVID.” That should say, “looked at a subclinical dose of Fluvoxamine” and found it didn’t work. A half-dose of Metformin probably wouldn’t either.
09:54 PM - Jun 10, 2023
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Satoshi Akima
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thread 8 Threaded Spouts
There are plenty of studies of viral persistence, showing the ongoing presence of virus for many months after the acute illness. In chronic hepatitis C, we treat with antivirals not for 2 weeks but for 12 to 24 weeks! https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(23)00142-X
09:52 PM - Jun 10, 2023
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Satoshi Akima
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thread 8 Threaded Spouts
More caveats about the COVID-OUT trial of Metformin for #longСОVΙD . The benefits of Metformin were diminished by vaccination but it was only taken for 14 days (“500 mg on day one, 500 mg twice daily on days 2–5, then 500 mg in the morning and 1000 mg in the evening up to day 14”).
09:49 PM - Jun 10, 2023
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Satoshi Akima
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It takes time to overcome the “merchants of doubt” who demand an RCT for everything—even if the RCT is unethical. We didn't need an RCT of smoking to believe it caused cancer. Why demand an RCT before believing that every COVID infection is doing you harm?
09:50 AM - Mar 30, 2023
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