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thread 1/16
#MedSpout
COVID19 and the INCREASED RISK of CANCERS

"Causal effects of COVID-19 on cancer risk: A Mendelian randomization study"

Figures illustrate the three fundamental assumptions of MR and depicts the flowchart of the present study.

https://onlinelibrary.wile... 🔗
03:06 AM - Feb 14, 2024 (Edited)
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thread 2/16
2) Fig. Forest plot of inverse-variance weighted Mendelian randomization analyzes of critically COVID-19 on the risk of cancers.
03:07 AM - Feb 14, 2024
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thread 3/16
Lung Cancers

THE TIME BOMB (2) :
COVID-19 may influence LUNG CANCER exacerbation by DEREGULATING GENES involved in the cell cycle.

https://www.sciencedirect.... 🔗
03:10 AM - Feb 14, 2024 (Edited)
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thread 4/16
Fig. The interaction network delineating the association between the proteins expressed by the DEGs and different respiratory tract diseases.
03:12 AM - Feb 14, 2024
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thread 5/16
Fig. The bar plot representation of the top 15 gene ontology terms of the shared DEGs
03:13 AM - Feb 14, 2024
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thread 6/16
Viruses in Tumor Tissues
Post INFECTION with covid19, viruses were found in the TUMOR tissues and acquired various MUTATIONS, predominantly in the SPIKE 😨

Establishment of a long-term replication model using lung cancer in 🐁

https://www.frontiersin.or... 🔗
03:16 AM - Feb 14, 2024
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thread 7/16
Amino acid mutations of parental SARS-CoV-2 S protein in cells during serial passage and in lung tumor tissues during long-term replication
03:17 AM - Feb 14, 2024
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thread 8/16
Viral clone isolation from plaques and analysis of amino acid mutations
03:17 AM - Feb 14, 2024
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thread 9/16
Differential replication of parental SARS-CoV-2 and its variants in Vero E6 and Calu-3 cells.
03:18 AM - Feb 14, 2024
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thread 10/16
Effects of parental SARS-CoV-2 and its variants on hACE2 transgenic mice
03:19 AM - Feb 14, 2024
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thread 11/16
DISCUSSION
"When we analyzed individual viral isolates, they had different combinations of mutations and showed higher replication in Calu-3 cells and decreased lethality in mouse challenge experiments compared with the parental SARS-CoV-2.
03:19 AM - Feb 14, 2024
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thread 12/16
These results support general speculation that SARS-CoV-2 variants acquire mutations that promote increased replication and decreased lethality as they adapt to their human host."

Thanks for reading 🙏
Emmanuel - from France
03:20 AM - Feb 14, 2024
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thread 13/16
COVID-19 + CANCER !

HSPA5 is a protein which is expressed in many cancers, making it a potential target for understanding the invasion and progression of cancer.

Fig. HSPA5 expression in 33 types of cancers.
03:21 AM - Feb 14, 2024
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thread 14/16
In the context of COVID-19 where individuals with cancer are particularly vulnerable, it has discovered that HSPA5 could be a receptor for SARS-COV-2.
03:23 AM - Feb 14, 2024
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thread 15/16
Fig. When the endoplasmic reticulum is stressed, HSPA5 is translocated to the cell surface and subsequently bound to the region IV (C480-C488) in the spike protein (S-protein) of SARS-CoV-2, thus acted as a receptor/entry protein for virus entry.
03:24 AM - Feb 14, 2024
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thread 16/16
"We reviewed the high expression of HSPA5 in the most cancers and the possibility of being invaded by the virus as a new coronavirus receptor"

Thanks for reading

"New progresses on cell surface protein HSPA5 in cancers and COVID-19"
03:25 AM - Feb 14, 2024
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In response to Cav4life '88.
I got interested as my SIL had a cancerous tumor that started growing in under 3 weeks after a (2nd) Covid19 infection. Got me on ⚠️

A friend of hers told her many people are getting cancer due to the vaccine (FALSE) - Been keeping an eye on cancer + covid19 ever since...
03:35 AM - Feb 14, 2024
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In response to Cav4life '88.
It's by Emmanuel from France. I understand a bit but wanted to share. Marked it a MedSpout so people know it's highly medical + technical information.
03:30 AM - Feb 14, 2024
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